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Items: 1 to 20 of 5607

1.
Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer’s Disease and Parkinson’s Disease Treatment (2011–2020)
Xuefei Li, Yanbo Yu, Zhude Tu
Molecules. 2021 Mar; 26(5): 1202. Published online 2021 Feb 24. doi: 10.3390/molecules26051202
PMCID:
PMC7956461
AbstractArticlePDF–14M
2.
Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15-Lipoxygenase inhibitors
Sahar A. Ali, Samir Mohamed Awad, Ahmed Mohammed Said, Shahenda Mahgoub, Heba Taha, Naglaa Mohamed Ahmed
J Enzyme Inhib Med Chem. 2020; 35(1): 847–863. Published online 2020 Mar 27. doi: 10.1080/14756366.2020.1742116
PMCID:
PMC7170299
AbstractArticlePDF–2.6M
3.
Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids
Dmytro Havrylyuk, Olexandra Roman, Roman Lesyk
Eur J Med Chem. 2016 May 4; 113: 145–166. Published online 2016 Feb 16. doi: 10.1016/j.ejmech.2016.02.030
PMCID:
PMC7115613
AbstractArticlePDF–1.6M
4.
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients
Marta Acebrón-García-de-Eulate, Joan Mayol-Llinàs, Matthew T. O. Holland, So Yeon Kim, Karen P. Brown, Chiara Marchetti, Jeannine Hess, Ornella Di Pietro, Vitor Mendes, Chris Abell, R. Andres Floto, Anthony G. Coyne, Tom L. Blundell
J Med Chem. Author manuscript; available in PMC 2023 Jul 25.
Published in final edited form as: J Med Chem. 2022 Feb 10; 65(3): 2149–2173. Published online 2022 Jan 26. doi: 10.1021/acs.jmedchem.1c01684
PMCID:
PMC7614804
AbstractArticlePDF–2.6M
5.
Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents
Eman S. Nossier, Hoda H. Fahmy, Nagy M. Khalifa, Wafaa I. El-Eraky, Marawan A. Baset
Molecules. 2017 Apr; 22(4): 512. Published online 2017 Mar 24. doi: 10.3390/molecules22040512
PMCID:
PMC6154115
AbstractArticlePDF–1.9M
6.
The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives
Stephanie Federico, Sara Redenti, Mattia Sturlese, Antonella Ciancetta, Sonja Kachler, Karl-Norbert Klotz, Barbara Cacciari, Stefano Moro, Giampiero Spalluto
PLoS One. 2015; 10(12): e0143504. Published online 2015 Dec 1. doi: 10.1371/journal.pone.0143504
PMCID:
PMC4666649
AbstractArticlePDF–3.9M
7.
Grafting of multiwalled carbon nanotubes with pyrazole derivatives: characterization, antimicrobial activity and molecular docking study
Nadia Hanafy Metwally, Gamal Riad Saad, Esraa Azmy Abd El-Wahab
Int J Nanomedicine. 2019; 14: 6645–6659. Published online 2019 Aug 20. doi: 10.2147/IJN.S182699
PMCID:
PMC6709384
AbstractArticlePDF–1.6M
8.
Synthesis and Diels–Alder Reactivity of 4-Fluoro-4-Methyl-4H-Pyrazoles
Nile S. Abularrage, Brian J. Levandowski, Ronald T. Raines
Int J Mol Sci. 2020 Jun; 21(11): 3964. Published online 2020 May 31. doi: 10.3390/ijms21113964
PMCID:
PMC7312747
AbstractArticlePDF–1.8M
9.
Organically Modified Silica with Pyrazole-3-carbaldehyde as a New Sorbent for Solid-Liquid Extraction of Heavy Metals
Smaail Radi, Said Tighadouini, Maryse Bacquet, Stéphanie Degoutin, Francine Cazier, Mustapha Zaghrioui, Yahia N. Mabkhot
Molecules. 2014 Jan; 19(1): 247–262. Published online 2013 Dec 24. doi: 10.3390/molecules19010247
PMCID:
PMC6271446
AbstractArticlePDF–569K
10.
Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent
Zhenli Min, Yue Zhu, Xing Hong, Zhijun Yu, Min Ye, Qiong Yuan, Xiamin Hu
Drug Des Devel Ther. 2020; 14: 2517–2534. Published online 2020 Jun 29. doi: 10.2147/DDDT.S244865
PMCID:
PMC7334020
AbstractArticlePDF–9.4M
11.
Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry
Chiara Brullo, Federica Rapetti, Olga Bruno
Molecules. 2020 Aug; 25(15): 3457. Published online 2020 Jul 29. doi: 10.3390/molecules25153457
PMCID:
PMC7435939
AbstractArticlePDF–2.4M
12.
Design, synthesis, and apoptosis-promoting effect evaluation of novel pyrazole with benzo[d]thiazole derivatives containing aminoguanidine units
Da Chuan Liu, Mei Jia Gao, Qiang Huo, Tao Ma, Ying Wang, Cheng Zhu Wu
J Enzyme Inhib Med Chem. 2019; 34(1): 829–837. Published online 2019 Mar 27. doi: 10.1080/14756366.2019.1591391
PMCID:
PMC6442160
AbstractArticlePDF–1.2M
13.
Discovery of 4,5-Dihydro-1H-thieno[2′,3′:2,3]thiepino [4,5-c]pyrazole-3-carboxamide Derivatives as the Potential Epidermal Growth Factor Receptors for Tyrosine Kinase Inhibitors
Jia Ke, Qi Lu, Xin Wang, Rui Sun, Zhe Jin, Xiaoyi Zhan, Jianshu Hu, David Chi-cheong Wan, Chun Hu
Molecules. 2018 Aug; 23(8): 1980. Published online 2018 Aug 8. doi: 10.3390/molecules23081980
PMCID:
PMC6222878
AbstractArticlePDF–1.4M
14.
Synthesis, Characterisation, and In Vitro Anticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase
Mohamed Jawed Ahsan, Habibullah Khalilullah, Sabina Yasmin, Surender Singh Jadav, Jeyabalan Govindasamy
Biomed Res Int. 2013; 2013: 239354. Published online 2013 Sep 9. doi: 10.1155/2013/239354
PMCID:
PMC3781846
AbstractArticlePDF–2.3M
15.
Design, Synthesis, and Antimicrobial Evaluation of Novel Pyrazoles and Pyrazolyl 1,3,4-Thiadiazine Derivatives
Ibrahim Ali M. Radini
Molecules. 2018 Sep; 23(9): 2092. Published online 2018 Aug 21. doi: 10.3390/molecules23092092
PMCID:
PMC6225469
AbstractArticlePDF–1020K
16.
Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and insilico studies
Ismail M. M. Othman, Mohamed A. M. Gad-Elkareem, Abd El-Galil E. Amr, Mohamed A. Al-Omar, Eman S. Nossier, Elsayed A. Elsayed
J Enzyme Inhib Med Chem. 2020; 35(1): 1491–1502. Published online 2020 Jul 16. doi: 10.1080/14756366.2020.1791842
PMCID:
PMC7470138
AbstractArticlePDF–2.2M
17.
Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents
Rawan Alnufaie, Hansa Raj KC, Nickolas Alsup, Jedidiah Whitt, Steven Andrew Chambers, David Gilmore, Mohammad A. Alam
Molecules. 2020 Jun; 25(12): 2758. Published online 2020 Jun 15. doi: 10.3390/molecules25122758
PMCID:
PMC7356691
AbstractArticlePDF–6.1M
18.
Synthesis, Molecular Docking and In Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine–Pyrazole Hybrid Derivatives
Eman M. Flefel, Walaa I. El-Sofany, Mahmoud El-Shahat, Arshi Naqvi, Eman Assirey
Molecules. 2018 Oct; 23(10): 2548. Published online 2018 Oct 6. doi: 10.3390/molecules23102548
PMCID:
PMC6222704
AbstractArticlePDF–1.7M
19.
Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review
Khalid Karrouchi, Smaail Radi, Youssef Ramli, Jamal Taoufik, Yahia N. Mabkhot, Faiz A. Al-aizari, M’hammed Ansar
Molecules. 2018 Jan; 23(1): 134. Published online 2018 Jan 12. doi: 10.3390/molecules23010134
PMCID:
PMC6017056
AbstractArticlePDF–34M
20.
Inhibition of microsomal oxidation of ethanol by pyrazole and 4-methylpyrazole in vitro. Increased effectiveness after induction by pyrazole and 4-methylpyrazole.
D E Feierman, A I Cederbaum
Biochem J. 1986 Nov 1; 239(3): 671–677. doi: 10.1042/bj2390671
PMCID:
PMC1147338
SummaryPage BrowsePDF–1.2M

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